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Greg Singer &
Mehrdad Hajibabaei
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KaKs analysis

This module uses the popular ratio of non-synonymous to synonymous substitutions (ω) at various taxonomic levels. This ratio has been used for estimating the degrees of selective pressure in molecular biosystematics. The module uses the program yn00 from the PAML package to calculate the ratio of non-synonymous to synonymous substitutions (ω) for all pairs within a set of aligned sequences. It then calculates the average and standard deviation of ω for all sequences pairs that belong to the same species, belong to the same genus, or belong to different genera.

Unfortunately this program is quite slow so please be patient when waiting for the result!